Metastasis: An evolving story

Chronic urticaria: an evolving story.

Albuminuria and diabetic nephropathy: an evolving story.

PIDs and cancer: an evolving story.

PIDs and cancer: an evolving story ---------------------------------------------------------------------------------------------------------------Luigi D. Notarangelo HARVARD MEDICAL SCHOOL Analysis of overall and site-specific cancer risk in patients with primary immunodeficiency diseases (PIDs) may shed light on the role played by the immune system in controlling malignancies. The association...

HIF2 and endocrine neoplasia: an evolving story.

In this issue of Endocrine-Related Cancer, Toledo et al. report the identification of activating mutations in the HIF2 (EPAS1) transcription factor in a subset of sporadic pheochromocytomas and paragangliomas. These findings add significantly to an evolving and complex story of the role of hypoxic gene response pathways in human endocrine neoplasia.

Host-Parasite Relationship in Cystic Echinococcosis: An Evolving Story

The larval stage of Echinococcus granulosus causes cystic echinococcosis, a neglected infectious disease that constitutes a major public health problem in developing countries. Despite being under constant barrage by the immune system, E. granulosus modulates antiparasite immune responses and persists in the human hosts with detectable humoral and cellular responses against the parasite. In vit...